A very informal space where I jot down thoughts on quantitative systems pharmacology, spatial statistics, and computational biology.
Scenarios, Contexts, and Observables in QSP
Now let’s talk about templated timing and treatment configurations. The reason we need those when we’re recording our observables is that oftentimes we’re not recording our observables in a natural state or wild-type state—a lot of times it’s under some sort of intervention or essentially exogenous forcing. There’s some sort...
What Should My Initial Conditions Be?
Let’s talk about initial conditions—time zero, or how to start the model, where to start the model at.
Dealing with Context Mismatches in QSP Parameterization
I’m thinking about parameters. The example I’m using is the rate of M2 to M1 polarization (macrophage polarization). This is often estimated by combining various different quantities across several different contexts. I’m thinking contexts have various axes like species, compartment or organ, treatment scenario, etc.